Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity

Cıftcı H., Can M., Ellakwa D. E., Suner S. C., Ibrahim M. A., Oral A., ...Daha Fazla

INVESTIGATIONAL NEW DRUGS, cilt.38, sa.5, ss.1326-1333, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s10637-020-00911-8
  • Dergi Adı: INVESTIGATIONAL NEW DRUGS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, ABI/INFORM, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1326-1333
  • Anahtar Kelimeler: Marine products, Cancer, Apoptosis, Tyrosine kinase inhibitors, CHRONIC MYELOGENOUS LEUKEMIA, SECONDARY METABOLITES, DARDANELLES, MORPHOLOGY, DISCOVERY, GROWTH, CANCER
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Marine natural products have drawn a great deal of attention as a vital source of new drugs for the last five decades. However, marine organisms in the seas surrounding Turkey (the Black Sea, the Aegean Sea and the Mediterranean Sea) haven't been yet extensively explored. In the present study, three marine organisms (Dysidea avara, Microcosmus sabatieri and Echinaster sepositus) were sampled from the Dardanelles (Turkish Straits System, Western Turkey) by scientific divers, transferred to the laboratory and then were extracted with 70% ethanol. The extracts were tested for their cytotoxic effect against K562, KMS-12PE, A549, and A375 cancer cell lines. The sponge extract elicited the most promising cytotoxic activity, thus it was further evaluated against H929, MCF-7, HeLa, and HCT116 cancer cells. Most of the designated cells showed a considerable sensitivity for the sponge extract particularly H929, K562, KMS-12PE and HeLa cells with IC50 less than 10 mu g/mL. On the contrary, the other two extracts exhibited no cytotoxic activity on all cells at 100 mu g/mL concentration. The sponge extract was tested for its capacity to induce apoptosis in cancer cells and to inhibit a panel of tyrosine kinases showing remarkable results. The outcome of this study represents a platform for discovery of new chemotherapeutic agents of marine natural origin.