Preoperative Systemic Inflammatory Markers in Different Brain Pathologies: An Analysis of 140 Patients

Kayhan A., Korkmaz T. Ş., Baran O., KEMERDERE R., YENİ S. N., TANRIVERDİ T.

TURKISH NEUROSURGERY, vol.29, no.6, pp.799-803, 2019 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.5137/1019-5149.jtn.24244-18.2
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.799-803
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

AIM: To analyze preoperative inflammatory markers including neutrophil, lymphocyte and platelet counts and neutrophil to lymphocyte (NLR) and platelet to lymphocyte (PLR) ratios in a group of patients with different brain pathologies and healthy controls. MATERIAL and METHODS: Above mentioned preoperative inflammatory markers were analyzed in a total of 140 patients included 39 with temporal lobe epilepsy, 37 with glioblastoma multiforme, 32 with grade-I meningioma and 32 with intracranial metastasis. Healthy controls included 30 subjects. The levels were compared between each patient group and between patients and controls. RESULTS: Significant higher neutrophil, platelet counts, NLR and PLR were found in glioma, meningioma and metastasis patients compared to epilepsy (p<0.05). On the other hand lymphocyte counts were significantly lower than epilepsy (p<0.05). PLR>120.78 was suggestive of metastasis rather than GBM. CONCLUSION: Preoperative inflammatory markers increase in different brain pathologies and metastasis show striking changes. PLR can have diagnostic value in differentiating metastasis from GBM.