Contribution of the STAT4 rs7574865 gene polymorphism to the susceptibility to autoimmune thyroiditis in healthy Turk population and psoriatic subgroups.


Hiz M. M., KILIÇ S., IŞIK S., Ogretmen Z., SILAN F.

Central-European journal of immunology, cilt.40, sa.4, ss.437-41, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5114/ceji.2015.57146
  • Dergi Adı: Central-European journal of immunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.437-41
  • Anahtar Kelimeler: psoriasis, polymorphism, Signal transducer and activator of transcription 4 (STAT4), autoimmune disease, JAK/STAT, autoimmune thyroiditis, rs7574865, SIGNAL TRANSDUCER, TRANSCRIPTION, ACTIVATOR, REQUIREMENT, DISRUPTION, CELLS, RISK, MICE
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Introduction: STAT4 is an important transcription factor that activates gene transcription as a response to cytokines. Recently, the influence of STAT4 gene on autoimmune disease has been widely studied in many different immune-related diseases. Autoimmune, metabolic and cardiovascular disorders are more common in psoriatic patients. STAT4 may be a unique gene that switches on in autoimmune-related thyroid disease in psoriatic patients.