Akademik Veri Yönetim Sistemi
10. UBAK, 10. Uluslararası Bilimsel Araştırmalar Kongresi- Fen ve Mühendislik Bilimlerithe 10th International Scientific Research Congress- Science and Engineering, Ankara, Türkiye, 11 - 12 Nisan 2021, sa.81, ss.61
Hydrogen sulfide (H2S), nitric oxide and carbon monoxide (CO), are important gaseous
signal molecules at the origin of life. For several centuries, H2S was known as a malodorous,
highly toxic gas without any biological and physiological function. This negative perception of
H2S has gained a different dimension with the pioneering work reported by Abe and Kimura in
1996. In this study, they reported the synthesis of H2S enzymatically in the brain of mammals,
its physiological concentration range and biological effects. Following this research output,
scientific interest has focused on the investigation of H2S as a critical signaling molecule
involved in many physiological processes. With the discovery of the release of enzymes
involved in H2S synthesis in gastrointestinal, neuronal, cardiovascular, respiratory and
endocrine systems, it determined that H2S has a crucial role on these systems. The discovery
of the release of enzymes involved in H2S synthesis in gastrointestinal, neuronal,
cardiovascular, respiratory and endocrine systems suggests that H2S may be a new therapeutic
target on these systems.
In this study, 10 new hydrogen sulfide releasing compounds were synthesized and their
structures were characterized by FT-IR, NMR, MS and melting point. The antineuroinflammatory effects of the compounds according to lipopolysaccharide (LPS) induced
NO release in the SIM-A9 microglia cell line were investigated. As a result, it has been observed
that most compounds suppressed LPS-induced NO releaseover 50%. Studies evaluating their
effects on inflammasome activation are on the way.