Research Information System
MATERIALS TODAY COMMUNICATIONS, vol.37, pp.1-11, 2023 (SCI-Expanded)
In this study, pH and redox sensitive biodegradable PPZs@Silibinin polymeric nanospheres were synthesized by
the polymerization reaction of Hexachlorocyclotriphosphazene (HCCP), Cystamine dihydrochloride (CA) and the
anticancer drug Silibinin as monomers. Later designed as a therapeutic system, this nano drug-carrier was also
loaded with Doxorubicin (Dox), a type of cancer drug. As a result, a drug self-delivery system (DSDS) was
developed, which had the property of biodegradation in tumor tissues thanks to the redox active disulfide bonds
in its structure from pH-sensitive nanospheres containing two anticancer drugs. Biodegradation-associated in
vitro release of cancer drug (Dox) from the Dox loaded PPZs@Silibinin nano drug-carrier was performed in the
presence of glutathione (GSH) at pH 6.5 and pH 7.4. While 93.06% Dox release was observed in pH 6.5 medium
containing 10 mM GSH in 24 h, this value was 56.60% in pH 7.4 + 10 mM GSH medium. In addition, clonogenic
analysis and cytotoxicity studies were performed on the MDA-MB-231 cell line to determine the anticancer
properties of PPZs@Silibinin loaded with Dox. It was determined that PPZs@Silibinin@Dox nanospheres containing
20.5 nM Dox for 0.75 μL are highly effective in MDA-MB-231 cells than free Dox