INORGANICA CHIMICA ACTA, sa.571, ss.1-10, 2024 (SCI-Expanded)
Metal-organic frameworks (MOFs) were prepared at room temperature using
natural occurring succinic acid derivatives, mercaptosuccinic acid
(MSA), and dimercaptosuccinic acid (DMSA), as organic linker with
Co(II), Ni(II), and Cu(II) as metal ions. The porosity, thermal, and
structural properties of MSA- and DMSA-based Co(II), Ni(II) and Cu(II)
MOFs were characterized and DMSA-Cu(II) MOFs were found to have higher
surface area and lower pore size values, 73.7 m2/g, and
12.7 nm, respectively. The metal ion amount in MSA and DMSA-based MOF
structures via Atomic Absorption Spectroscopy (AAS) analysis revealed an
increased amount of Metal ions with the increasing number of −SH groups
in the MOF structures. The antioxidant activities of DMSA-based MOFs
were measured higher than MSA-based MOFs by ABTS•+scavenging assay. DMSA-Cu(II) MOFs showed higher antioxidant activity with 4.58 ± 0.13 μmol trolox g−1. Both MSA- and DMSA-MOFs presented hemocompatible behavior at concentrations < 100 µg/mL. Also, against B. subtilis and S. aureus
bacteria strains, DMSA-Cu(II) MOFs showed higher antimicrobial activity
than all the other prepared MSA- and DMSA-based MOFs with a MIC value
of 31 µg/mL and MBC value of 125 µg/mL for both bacteria strains.
Moreover, the MSA- and DMSA-MOFs at 250 μg/mL concentration retain about 80 % cell viability for L929 fibroblast cells at 24 incubation time.