Degradable poly(catechin) nanoparticles as a versatile therapeutic agent

SUNER S. C., ŞAHİNER M., Mohapatra S., Ayyala R. S., Bhethanabotla V. R., ŞAHİNER N.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.71, sa.14, ss.1104-1115, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 14
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/00914037.2021.1941957
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.1104-1115
  • Anahtar Kelimeler: Catechin, CAT nanoparticles, antioxidant, cancer therapy, metal chelating, antidiabetic
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Poly(catechin) (p(CAT)) nanoparticles (NPs), 173 +/- 4 nm was prepared as a therapeutic agent with hydrolytic degradability affording sustainable CAT release over 20 d at carcinogenic conditions, pH 5.5 and 37.5 degrees C. Cell viability studies on MC38 colon cancer cells revealed the anticancer potential of p(CAT) NPs with 691 mu g/mL IC50 value while being well-tolerated by nonmalignant CCD841 CoN colon cells at 72 h incubation-time. P(CAT) NPs showed effective antioxidant capacity with 241 +/- 7 and 456 +/- 54 mu g/mL of GA equivalency of total phenol content (TPC), and total flavonoid content (TFC) values and 1.19 +/- 0.8 mu mol/g Trolox equivalent antioxidant capacity by 2,2'-Azino-bis-(3-ethylbenzothioazoline-6-sulfonic acid (ABTS(center dot+)) scavenging assay.