BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, vol.86, no.3, pp.321-326, 2020 (SCI-Expanded)
Introduction: Many studies have been done on proteomics, genomics, epigenetic, immuno-genetics in many body fluids. Among these, circulating cell-free DNA (ccfDNA) entered the literature in 1948, but it has not been studied for many years due to technological deficiencies. Following recent advances, geno-metastasis has been mentioned and new research is needed in this area. ccfDNA is known to be an important biomolecule in this regard.