Correlation between the pathologic features of radical retropubic prostatectomy specimens and free/total PSA ratios Radi̇kal retropubi̇k prostatektomi̇sonrasi elde edi̇len prostat dokusuna ai̇t patoloji̇k özeli̇kler i̇le ameli̇yat önceṡi serbest/total prostat spesi̇fi̇k anti̇jen orani arasindak̇i i̇li̇şk̇i

Öztürk B., Özden C., Koşan M., Yariş M., Adsan Ö., Memiş A.

Turk Uroloji Dergisi, cilt.33, sa.1, ss.13-17, 2007 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 1
  • Basım Tarihi: 2007
  • Dergi Adı: Turk Uroloji Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.13-17
  • Anahtar Kelimeler: Prostate cancer, PSA, Radical prostatectomy
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır

Özet

Introduction: There are many reports about the prognostic significance of the pathologic features of radical retropubic prostatectomy specimens in patients with localized prostate cancer. In our study we evaluated the relation between the preoperative free/total prostate specific antigen ratio (f/t PSA) and pathologic features of radical retropubic prostatectomy specimens. Materials and Methods: We retrospectively evaluated the data of 109 radical retropubic prostatectomy patients. Patients were divided into 3 groups according to their PSA levels (<10, 10-15, >15 ng/dl) and f/t PSA ratio (<0.10, 0.10-0.20, >0.20). We investigated the distribution of the patients to the groups according to pathologic features of radical retropubic prostatectomy specimens such as surgical margin positivity (SMP), extracapsular extension (ECE), seminal vesicle involvement (SVI), perineural invasion and pathologic stage. Results: Mean patient age was 61.6±5.9 years, mean PSA level was 10.6±6.7 ng/ml and mean f/t PSA ratio was 0.16±0.13. There was not any statistically significant difference between the PSA groups regarding the pathologic features of radical retropubic prostatectomy specimens (p>0.05). Pathological stage, SMP, ECE and SVI were higher in f/t PSA ratio <0.10 (p<0.05). Conclusion: We think that preoperative f/t PSA ratio could be a useful determinant for estimating the prognosis of radical retropubic prostatectomy patients according to pathological features of surgical specimens. Further studies with larger number of patients are needed to confirm these results.