Voltammetric Determination of Favipiravir Used as an Antiviral Drug for the Treatment of Covid-19 at Pencil Graphite Electrode

Ersan T., GİRAY DİLGİN D., Kumrulu E., Kumrulu U., DİLGİN Y.

ELECTROANALYSIS, vol.35, no.4, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.1002/elan.202200295
  • Journal Name: ELECTROANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Keywords: COVID-19, Favipiravir, Pencil graphite electrode, Differential Pulse Voltammetry, SENSING PLATFORM, QUANTIFICATION, HPLC, UV
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

This work describes the sensitive voltammetric determination of favipiravir (FAV) based on its reduction for the first time with a low-cost and disposable pencil graphite electrode (PGE). In addition, the determination of FAV was also performed based on its oxidation. Differential pulse (DP) voltammograms recorded in 0.5 M H2SO4 for the reduction of FAV show that peak currents increase linearly in the range of 1.0 to 600.0 mu M with a limit of detection of 0.35 mu M. The acceptable recovery values (98.9-106.0 %) obtained from a pharmaceutical tablet, real human urine, and artificial blood serum samples spiked with FAV confirm the high accuracy of the proposed method.