Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties


KAMACI M., KAYA İ.

POLYMERS FOR ADVANCED TECHNOLOGIES, vol.34, no.2, pp.779-788, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.1002/pat.5930
  • Journal Name: POLYMERS FOR ADVANCED TECHNOLOGIES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.779-788
  • Keywords: chitosan, drug delivery, hybrid hydrogel, polyurethane
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

In the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5-fluorouracil. The fabricated hydrogels were characterized via FT-IR and SEM analysis. Besides, the thermal, mechanical, and wettability properties, water uptake, biodegradation, protein absorption, drug loading, and release behaviors of the hybrid hydrogels were studied. The obtained results indicated that the fabricated hybrid hydrogels have exhibited good mechanical, hydrophilic, water uptake, and biodegradation behaviors. The hybrid hydrogels also showed 50% drug release amounts and they could be a good candidate for the controlled delivery of 5-FU due to these properties.