Degradable, biocompatible, and antibacterial polygalacturonic acid/polyethyleneimine polyplex particles

Suner S. S.

Polymers for Advanced Technologies, cilt.34, sa.6, ss.2001-2009, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/pat.6027
  • Dergi Adı: Polymers for Advanced Technologies
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.2001-2009
  • Anahtar Kelimeler: antibacterial polymeric material, biocompatible, polyethyleneimine, polygalacturonic acid, polyplex particles
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Anionic polygalacturonic acid (PGA), a prebiotic for healthy microbiota, and cationic polyethyleneimine (PEI), a strong antimicrobial polymer against harmful infections, were ionically crosslinked to prepare biocompatible and antibacterial polygalacturonic acid/polyethyleneimine (PGA/PEI) polyplex particles. The PGA/PEI particles were spherical in shape and had a wrinkled surface with a micron size range of particles from 9 to 0.6 μm. The PGA/PEI polyplex particle was degradable under more acidic and basic conditions but was highly stable between pH 3 and 7. The prepared PGA/PEI polyplex particles are found compatible for intravenous applications with hemolysis rate of less than 1% and almost 100% blood clotting index values up to 1 mg/mL concentration. Similarly, no significant toxicity was found on L929 fibroblast cells for 24 h incubation time in the presence of 1 mg/mL concentration of the PGA/PEI polyplex particles. As an antibacterial material, the PGA/PEI polyplex particles totally prevented the growth of Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Due to the antibacterial, biocompatible, blood compatibility, and degradability, the PGA/PEI polyplex particles can be utilized in wide range of application such as particularly wound dressing, cosmetic and health care products, and drug delivery applications.