Background: Odontogenic myxoma is a rare, benign neoplasm and is often located in the maxillofacial region centrally most common in the mandible. Soft tissue localization that can be classified as a peripheral myxoma is rarely seen than the central localization. Peripheral myxoma is slowly growing and less aggressive compared to the central myxoma and has a low recurrence rate. Case report: In this presentation, the patient with a peripheral odontogenic myxoma of the posterior maxillary gingiva was presented with histological findings following surgery, and the clinical differences and characteristics of the various types of myxomas were discussed by a review of the literature. © Springer-Verlag 2008.