Repurposing ivermectin: a new hope for glioblastoma multiforme?

Mohtashami E., Bibak B., Sanati M., Afshari S., Kahkhaie K. R., Vahedi M. M., ...Daha Fazla

Medicinal Chemistry Research, cilt.34, sa.8, ss.1603-1615, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 34 Sayı: 8
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s00044-025-03435-z
  • Dergi Adı: Medicinal Chemistry Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Veterinary Science Database
  • Sayfa Sayıları: ss.1603-1615
  • Anahtar Kelimeler: Anticancer, Antiproliferative, Glioblastoma multiforme, Ivermectin, Macrocyclic lactone
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Ivermectin is the most extensively researched macrocyclic lactone due to its potential anticancer and antiparasitic use. Nonetheless, there are more compounds within this family, including doramectin and abamectin. In the current era of medicinal repurposing, ivermectin has received renewed focus following its initial development for the treatment of parasitic conditions such as scabies, elephantiasis, and river blindness. Recent studies indicate that ivermectin may inhibit the proliferation of specific tumor cells by regulating many signaling pathways implicated in cancer progression. Despite the growing body of research on the topic, critical issues about its anticancer processes remain unresolved. Our study focused on ivermectin, its mechanisms of action, and its potential uses against glioblastoma multiforme (GBM).