Antibiotic susceptibility patterns among respiratory isolates of Gram-negative bacilli in a Turkish university hospital
BMC MICROBIOLOGY, cilt.4, 2004 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4
- Basım Tarihi: 2004
- Doi Numarası: 10.1186/1471-2180-4-32
- Dergi Adı: BMC MICROBIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
Background: Gram-negative bacteria cause most nosocomial respiratory infections. At the University of Cumhuriyet, we examined 328 respiratory isolates of Enterobacteriaceae and Acinetobacter baumanii organisms in Sivas, Turkey over 3 years. We used disk diffusion or standardized microdilution to test the isolates against 18 antibiotics.
Results: We cultured organisms from sputum (54%), tracheal aspirate (25%), and bronchial lavage fluid (21%). The most common organisms were Klebsiella spp (35%), A. baumanii (27%), and Escherichia coli (15%). Imipenem was the most active agent, inhibiting 90% of Enterobacteriaceae and A. baumanii organisms. We considered approximately 12% of Klebsiella pneumoniae and 21% of E. coli isolates to be possible producers of extended-spectrum beta-lactamase. K. pneumoniae isolates of the extended-spectrum beta-lactamase phenotype were more resistant to imipenem, ciprofloxacin, and tetracycline in our study than they are in other regions of the world.
Conclusions: Our results suggest that imipenem resistance in our region is growing.