This study was conducted to investigate the relationship between health professionals' perception of social stigma, and compassion satisfaction, burnout, compassion fatigue and intention to leave the profession during the COVID-19 pandemic. This study is a descriptive online study. It was conducted with 420 health professionals working in a university hospital serving as a pandemic hospital in a province of Turkey. The study data were collected through an online questionnaire including the Personal Information Form, Social Stigma Perception Scale, Professional Quality of Life Scale, and Scale of Intentions to Leave the Profession. Social stigma perception was the negative predictor of compassion fatigue, and the positive predictor of burnout, compassion fatigue and intention to leave the profession.