Comparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgery


ÖZKURT Y., Oral Y., Karacan O., Comez A., Dogan O. K.

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE, vol.34, no.1, pp.21-23, 2008 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1097/icl.0b013e3180587e0a
  • Journal Name: EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.21-23

Abstract

Purpose. To compare the effects of dorzolamide-timolol combination and brimonidine on intraocular pressure (IOP) after phacoemulsification surgery. Methods. This prospective, randomized study included 69 eyes of 43 patients undergoing phacoemulsification and foldable intraocular lens implantation. Twenty-one patients were women and 22 were men. The mean patient age was 69.7 +/- 12.4 years. Patients were randomly assigned to one of three treatment groups preoperatively. Group A (n = 23) received one drop of dorzolamide-timolol fixed combination and group B (n = 23) received one drop of brimonidine tartrate 0.2% immediately after surgery. In group C (n = 23), patients received no treatment and served as a control group. IOP was measured by Goldmann applanation tonometry 6 hours and 24 hours after surgery. Results. Six hours after Surgery, the mean IOP was significantly lower in group A (16.3 +/- 2.9 mm Hg) than in groups B (20.6 +/- 2.9 mm Hg) and C (24.6 +/- 5.4 mm Hg). However, 24 hours after surgery, the mean IOP was higher in group C (19.8 +/- 4.7 mm Hg) than in the other two groups (14.1 +/- 2.8 mm Hg in group A and 17.5 +/- 2.7 mm Hg in group B). Conclusions. Prophylactic treatment with dorzolamide-timolol fixed combination was more effective than brimonidine in reducing IOP 6 hours and 24 hours after phacoemulsification surgery.