Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

Tokay, Esra; Güngör, TUĞBA; Hacioglu, Nelin; Cömert Önder, FERAH; Gullhan, Unzile; Tok, Tugba; Celik, Ayhan; Ay, MEHMET; Kockar, Feray

doi:10.1016/j.ejmech.2019.111937

Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

Atıf İçin Kopyala

Tokay E., Güngör T., Hacioglu N., Cömert Önder F., Gullhan U. G., Tok T. T., ...Daha Fazla

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.187, 2020 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 187
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.ejmech.2019.111937
Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: Dinitroaniline, Prodrug, Ssap-NtrB, Nitroreductase, Enzymatic activity, Cytotoxicity, Prostate cancer, In silica studies
Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This strategy uses prodrugs which are safe for normal cells and form toxic metabolites (drugs) after selective reduction by enzymes in tumor tissues.