Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer


Tokay E., Güngör T., Hacioglu N., Cömert Önder F., Gullhan U. G. , Tok T. T. , ...More

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.187, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 187
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ejmech.2019.111937
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Dinitroaniline, Prodrug, Ssap-NtrB, Nitroreductase, Enzymatic activity, Cytotoxicity, Prostate cancer, In silica studies, DERIVATIVES, MUSTARDS, NITRO

Abstract

Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This strategy uses prodrugs which are safe for normal cells and form toxic metabolites (drugs) after selective reduction by enzymes in tumor tissues.