Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

Tokay, Esra; Güngör, TUĞBA; Hacioglu, Nelin; Cömert Önder, FERAH; Gullhan, Unzile; Tok, Tugba; Celik, Ayhan; Ay, MEHMET; Kockar, Feray

doi:10.1016/j.ejmech.2019.111937

Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

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Tokay E., Güngör T., Hacioglu N., Cömert Önder F., Gullhan U. G., Tok T. T., ...More

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.187, 2020 (SCI-Expanded)

Publication Type: Article / Article
Volume: 187
Publication Date: 2020
Doi Number: 10.1016/j.ejmech.2019.111937
Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
Keywords: Dinitroaniline, Prodrug, Ssap-NtrB, Nitroreductase, Enzymatic activity, Cytotoxicity, Prostate cancer, In silica studies, DERIVATIVES, MUSTARDS, NITRO
Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This strategy uses prodrugs which are safe for normal cells and form toxic metabolites (drugs) after selective reduction by enzymes in tumor tissues.