Feasibility of Diffusion-weighted Magnetic Resonance Imaging for Differentiating Idiopathic Granulomatous Mastitis From Malignant Breast Lesions İdiyopatik Granülomatöz Mastitin Malign Meme Lezyonlarından Ayırılmasında Difüzyon Ağırlıklı Manyetik Rezonans Görüntülemenin Uygulanabilirliği

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Rona G., Arifoğlu M., Voyvoda N., Kökten Ş., ÇETİN K.

Medical Journal of Bakirkoy, vol.19, no.1, pp.35-40, 2023 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.4274/bmj.galenos.2023.2021.12-7
  • Journal Name: Medical Journal of Bakirkoy
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE
  • Page Numbers: pp.35-40
  • Keywords: Granulomatous mastitis, magnetic resonance imaging, diffusion-weighted MRI, breast carcinoma
  • Çanakkale Onsekiz Mart University Affiliated: Yes


Objective: Idiopathic granulomatous mastitis (IGM) is an inflammatory breast disease that is often challenging to differentiate from malignancy. This study investigated the role of diffusion-weighted (DW) magnetic resonance imaging in differentiating IGM from malignant breast lesions. Methods: This retrospective study included 82 female patients with IGM [with a mean age of 33.48 years, minimum (min): 22 - maximum (max): 58 years] and 85 female patients with breast cancer (with a mean age of 48.14 years, min: 31 - max: 79 years). The diagnoses of all patients were confirmed by biopsy, including 114 IGM lesions and 115 malignant lesions in the analysis. DW sequences were acquired with b-values of 0 and 1000 mm2/sec on a 1.5 T device. The apparent diffusion coefficient (ADC) values of the lesions were measured manually by placing multiple regions of interest of 50-100 mm2 in the target lesions and contralateral normal parenchyma. Results: The ADC values of both IGM (1.119±0.454x10-3 mm2/s) and malignant lesions (1066±0.610x10-3 mm2/s) were lower than those of normal parenchyma. The ADC values of the mastitis group were significantly higher than the ADC values of the carcinoma group (p=0.00). The inter-observer (r=0.627) and intra-observer (r=0.775) agreement of ADC measurements were strong. Conclusion: DW imaging is a useful noninvasive technique to differentiate between IGM and breast carcinoma.