JOURNAL OF PEDIATRIC SURGERY, vol.40, no.10, pp.1632-1636, 2005 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF PEDIATRIC SURGERY
myosin heavy chains, smooth muscle, ureteropelvic junction obstruction, HEAVY-CHAIN ISOFORMS, MESENCHYMAL-EPITHELIAL INTERACTIONS, RENAL PELVIS, EXPRESSION, BLADDER, HYDRONEPHROSIS, INNERVATION, URETER, TISSUE
Background/Purpose: Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis. Previous studies have reported that the excess amount of collagen restricting mobility and resiliency of the UPJ is the result of an impaired collagen production by anomalous smooth muscle cells (SMCs). Our purpose was to evaluate the role of SMC differentiation in the pathogenesis of UPJ obstruction.