Structural changes of smooth muscle in congenital ureteropelvic junction obstruction

Hosgor M., Karaca I., Ulukus C., Ozer E., Ozkara E., Sam B., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.40, no.10, pp.1632-1636, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 10
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jpedsurg.2005.06.025
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1632-1636
  • Keywords: myosin heavy chains, smooth muscle, ureteropelvic junction obstruction, HEAVY-CHAIN ISOFORMS, MESENCHYMAL-EPITHELIAL INTERACTIONS, RENAL PELVIS, EXPRESSION, BLADDER, HYDRONEPHROSIS, INNERVATION, URETER, TISSUE
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Background/Purpose: Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis. Previous studies have reported that the excess amount of collagen restricting mobility and resiliency of the UPJ is the result of an impaired collagen production by anomalous smooth muscle cells (SMCs). Our purpose was to evaluate the role of SMC differentiation in the pathogenesis of UPJ obstruction.