Structural changes of smooth muscle in congenital ureteropelvic junction obstruction


Hosgor M., Karaca I., Ulukus C., Ozer E., Ozkara E., Sam B., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.40, no.10, pp.1632-1636, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 10
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jpedsurg.2005.06.025
  • Title of Journal : JOURNAL OF PEDIATRIC SURGERY
  • Page Numbers: pp.1632-1636
  • Keywords: myosin heavy chains, smooth muscle, ureteropelvic junction obstruction, HEAVY-CHAIN ISOFORMS, MESENCHYMAL-EPITHELIAL INTERACTIONS, RENAL PELVIS, EXPRESSION, BLADDER, HYDRONEPHROSIS, INNERVATION, URETER, TISSUE

Abstract

Background/Purpose: Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis. Previous studies have reported that the excess amount of collagen restricting mobility and resiliency of the UPJ is the result of an impaired collagen production by anomalous smooth muscle cells (SMCs). Our purpose was to evaluate the role of SMC differentiation in the pathogenesis of UPJ obstruction.