The Potential Therapeutic Effects of Agmatine, Methylprednisolone, and Rapamycin on Experimental Spinal Cord Injury

FIRAT T., Kukner A., AYTÜRK N., GEZİCİ A. R., Serin E., Ozogul C., ...More

CELL JOURNAL, vol.23, no.6, pp.701-707, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.22074/cellj.2021.7198
  • Journal Name: CELL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.701-707
  • Keywords: Agmatine, Methylprednisolone, Rapamycin, Spinal Cord Injury, PROMOTES LOCOMOTOR RECOVERY, ISCHEMIA-REPERFUSION INJURY, OXIDATIVE STRESS, SODIUM SUCCINATE, AUTOPHAGY, INFLAMMATION, APOPTOSIS, RATS, INHIBITION, ACTIVATION
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Objective: In spinal cord injury (SCI), the primary mechanical damage leads to a neuroinflammatory response and the secondary neuronal injury occurs in response to the release of reactive oxygen species (ROS). In addition to the suppression of inflammation, autophagy plays a significant role in the survival of neurons during secondary SCI. The present study aimed to examine the anti-inflammatory and autophagic effects of agmatine and rapamycin in SCI and to compare the results with methylprednisolone (MP) used in the clinic.