The Potential Therapeutic Effects of Agmatine, Methylprednisolone, and Rapamycin on Experimental Spinal Cord Injury

FIRAT T., Kukner A., AYTÜRK N., GEZİCİ A. R., Serin E., Ozogul C., ...Daha Fazla

CELL JOURNAL, cilt.23, sa.6, ss.701-707, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.22074/cellj.2021.7198
  • Dergi Adı: CELL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.701-707
  • Anahtar Kelimeler: Agmatine, Methylprednisolone, Rapamycin, Spinal Cord Injury, PROMOTES LOCOMOTOR RECOVERY, ISCHEMIA-REPERFUSION INJURY, OXIDATIVE STRESS, SODIUM SUCCINATE, AUTOPHAGY, INFLAMMATION, APOPTOSIS, RATS, INHIBITION, ACTIVATION
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Objective: In spinal cord injury (SCI), the primary mechanical damage leads to a neuroinflammatory response and the secondary neuronal injury occurs in response to the release of reactive oxygen species (ROS). In addition to the suppression of inflammation, autophagy plays a significant role in the survival of neurons during secondary SCI. The present study aimed to examine the anti-inflammatory and autophagic effects of agmatine and rapamycin in SCI and to compare the results with methylprednisolone (MP) used in the clinic.