L-carnitine in experimental retinal ischemia-reperfusion injury


ALAGÖZ G., Celiker U., İLHAN N., YEKELER H., Demir T. , CELİKER H.

OPHTHALMOLOGICA, vol.216, no.2, pp.144-150, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 216 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1159/000048315
  • Title of Journal : OPHTHALMOLOGICA
  • Page Numbers: pp.144-150

Abstract

The effect of L-carnitine on retinal ischemia-reperfusion injury was evaluated in guinea pigs. 90 min of pressure-induced retinal ischemia followed by 24 h of reperfusion was established in both eyes of 2 groups of animals receiving either L-carnitine (100 mg/kg repeated in 5 doses) or saline intraperitoneally. After enucleation of all the eyes, including those of a control group, malonyldialdehyde (MDA) levels and the thickness of the retinal tissue were measured in 3 groups. The mean MDA value and the tissue thickness of the L-carnitine-treated group were statistically insignificant versus the control group (p > 0.05 and p > 0.05, respectively). However, these values were significantly different in the group receiving saline versus the control group and that receiving L-carnitine (p < 0.001, p < 0.001 and p < 0.001, p < 0.001 respectively). L-Carnitine might be an alternative drug for ischemia-reperfusion injury of the retina. Copyright (C) 2002 S. Karger AG, Basel.