L-carnitine in experimental retinal ischemia-reperfusion injury

ALAGÖZ G., Celiker U., İLHAN N., YEKELER H., Demir T. , CELİKER H.

OPHTHALMOLOGICA, cilt.216, ss.144-150, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 216 Konu: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1159/000048315
  • Sayfa Sayıları: ss.144-150


The effect of L-carnitine on retinal ischemia-reperfusion injury was evaluated in guinea pigs. 90 min of pressure-induced retinal ischemia followed by 24 h of reperfusion was established in both eyes of 2 groups of animals receiving either L-carnitine (100 mg/kg repeated in 5 doses) or saline intraperitoneally. After enucleation of all the eyes, including those of a control group, malonyldialdehyde (MDA) levels and the thickness of the retinal tissue were measured in 3 groups. The mean MDA value and the tissue thickness of the L-carnitine-treated group were statistically insignificant versus the control group (p > 0.05 and p > 0.05, respectively). However, these values were significantly different in the group receiving saline versus the control group and that receiving L-carnitine (p < 0.001, p < 0.001 and p < 0.001, p < 0.001 respectively). L-Carnitine might be an alternative drug for ischemia-reperfusion injury of the retina. Copyright (C) 2002 S. Karger AG, Basel.