THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS


Rona G., Arifoglu M., Voyvoda N., ÇETİN K., Damgaci L.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, 2022 (ESCI) identifier

Abstract

Objective: The aim of this study was to investigate the role of diffusion-weighted magnetic resonance imaging (DW MRI) with an apparent diffusion coefficient (ADC) map in evaluating the re-sponse to treatment of steroid-treated idiopathic granulomatous mastitis (IGM) lesions.Materials and Methods: This retrospective study included 99 le-sions of 58 female patients (average age: 32.91 years; range: 22-55 years) with biopsy-proven IGM. Patients were treated with oral and topical steroids. All pre-treatment and post-treatment MR exam-inations were evaluated. The maximal size of the masses and non-mass enhancement (NME) lesions were measured. Patients were classified as complete response (CR), partial response (PR), and non-response (NR) according to the dynamic contrast-enhanced (DCE) MR findings after treatment.Results: ADC values of areas occupied by IGM (0.933 +/- 0.317x10-3 mm2/sec) were lower than contralateral normal parenchyma (1.259 +/- 0.423x10-3 mm2/sec). Twenty-two (22.22%) of the lesions were in the NR group, 30 (30.30%) in the PR group, and 47 (47.47%) in the CR group. There was no significant difference between the pre-treatment ADC values in NR, PR, and CR groups (p=0.228). There was a significant difference between the pre-treatment and post-treatment ADC values in the PR groups (p=0.001).Conclusion: DW MR imaging in IGM is a useful method to monitor the response to treatment. However, it is not successful in predict-ing response to treatment.