Presence of Peripheral Neuropathy Does Not Affect Urine 6-Sulfatoxymelatonin Levels in Type 2 Diabetics

Kurt K., Karakılıç E., Ocak Ö., Çakına S.

NEUROENDOCRINOLOGY LETTERS, vol.42, no.1, pp.33-42, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2021
  • Journal Indexes: Science Citation Index Expanded, Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.33-42
  • Keywords: Diabetic neuropathy, Distal symmetrical polyneuropathy, Melatonin, 6-sulfatoxymelatonin, MELATONIN SYNTHESIS IMPAIRMENT, OBSTRUCTIVE SLEEP-APNEA, OXIDATIVE STRESS, RATS, NEPHROPATHY, INSULIN, ACID


BACKGROUND: Oxidative stress plays a crucial role in the pathogenesis of diabetic peripheral neuropathy. Melatonin is one of the most powerful antioxidant substances and its role in the pathogenesis of diabetes has been the focus of much research. However, no data exist on melatonin levels in diabetic peripheral neuropathy. We investigated how levels of urinary 6-sulfatoxymelatonin, the main metabolite of melatonin, differed in diabetic peripheral neuropathy.