Presence of Peripheral Neuropathy Does Not Affect Urine 6-Sulfatoxymelatonin Levels in Type 2 Diabetics

Kurt K., Karakılıç E., Ocak Ö., Çakına S.

NEUROENDOCRINOLOGY LETTERS, cilt.42, sa.1, ss.33-42, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 1
  • Basım Tarihi: 2021
  • Dergi Adı: NEUROENDOCRINOLOGY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.33-42
  • Anahtar Kelimeler: Diabetic neuropathy, Distal symmetrical polyneuropathy, Melatonin, 6-sulfatoxymelatonin, MELATONIN SYNTHESIS IMPAIRMENT, OBSTRUCTIVE SLEEP-APNEA, OXIDATIVE STRESS, RATS, NEPHROPATHY, INSULIN, ACID
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

BACKGROUND: Oxidative stress plays a crucial role in the pathogenesis of diabetic peripheral neuropathy. Melatonin is one of the most powerful antioxidant substances and its role in the pathogenesis of diabetes has been the focus of much research. However, no data exist on melatonin levels in diabetic peripheral neuropathy. We investigated how levels of urinary 6-sulfatoxymelatonin, the main metabolite of melatonin, differed in diabetic peripheral neuropathy.