Synthesis And Enlightenment Of Structures Of β-Lactame Derivative Compounds Containing Naphthaline

Berber N.

5.International Scientific Research Congress, Bursa, Türkiye, 22 - 23 Şubat 2025, ss.30, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Bursa
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.30
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

β-Lactam antibiotics are used for the prevention and treatment of bacterial infections caused by susceptible organisms. They show their antibacterial properties by inhibiting the cell wall of bacteria. They are generally formed by combining imine and ketene. Within the scope of the study, firstly, imine was obtained by using 5 different aromatic aldehydes (4-Ph-, 4-OMe-, 4-F, 4-CH3- and 4-NO2) starting from 1-naphthylamine in the presence of methanol under hot conditions and then 10 different β-lactam derivatives were obtained by reacting the obtained imines with dichloroacetylchloride and acetoxyacetylchloride in the presence of benzene. The structures of the obtained compounds were elucidated by FT-IR, 1H NMR and 13C NMR spectra.