Background/Objective. Cisplatin is a widely used chemotherapeutic agent, but its ototoxicity side effect can occur in the majority
of patients. Lots of agents were tried to prevent this, but there is not a routine treatment modality yet. The aim of this study was
to evaluate the otoprotective effect of sertraline, which is an antidepressant with neuroprotective effects, against cisplatin, in rats.
Design. Experimental animal study. Material and Methods. Forty-eight rats were randomly separated in two groups as groups I
and II. Group I was identified as the control group and only a single dose of intraperitoneal cisplatin was administered. In group
II, in addition to cisplatin, sertraline was administered to the rats through an oral cannula for ten-day period. Distortion product
otoacoustic emission measurements were performed at the first day and the 10th day. Results. When the ototoxicity rates after
cisplatin in group I and group II in distortion product otoacoustic emission measurements were compared, it was statistically
significantly lower in group II in frequencies of 5652, 6165, 6726, 7336, and 7996Hz (?? < 0.05). Conclusion. Sertraline seems to
have a protective effect on cisplatin ototoxicity and could be used to prevent the ototoxicity and also to treat the depression that
occurred in cancer patients together.