DOUBLE TRANSLOCATION: AN INTERESTING FAMILY HISTORY

UYSAL A. O., ULUDAĞ A., SILAN F., Ercelen N., Zafer C., ÖZDEMİR Ö.

BALKAN JOURNAL OF MEDICAL GENETICS, vol.16, no.1, pp.77-80, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.2478/bjmg-2013-0022
  • Journal Name: BALKAN JOURNAL OF MEDICAL GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.77-80
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation carriers. In this present case, we describe an interesting family history which included three generations. A couple, married for 4 years, was referred to the genetic clinic due to infertility and family chromosome anomalies. A GTG-band chromosome analysis indicated that the male partner's karyotype was 45, XY, t(3; 18)(q11; ptel)t(13; 14)(q10; q10). The same double balanced translocation was found in two others family members.