The expression of LMO2 protein in acute B-cell and myeloid leukemia

ÇOBANOĞLU Ü., SÖNMEZ M., Ozbas H. M., Erkut N., ÇAN G.

HEMATOLOGY, cilt.15, sa.3, ss.132-134, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1179/102453309x12583347113618
  • Dergi Adı: HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.132-134
  • Anahtar Kelimeler: Acute leukemia, LMO2 protein, LIM-DOMAIN, TRANSCRIPTION
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır

Özet

LIM domain only-2 (LMO2) is an important regulator of hematopoietic stem cell development. LMO2 is also expressed in blast cells of different types of acute leukemia. Here, we analyzed the LMO2 protein expression in acute myeloid leukemia (AML) and B-cell acute lymphoblastic leukemia (B-ALL) and examined whether the LMO2 protein expression can predict outcomes of patients with acute leukemia. Patients with acute B-ALL (22 cases) and AML (57 cases) were examined using immunohistochemistry for LMO2 on paraffin-embedded bone marrow biopsies. We report that LMO2 protein is expressed in a significant proportion of B-ALL and AML and the staining of LMO2 protein does not predict survival in acute leukemia.