Association between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients

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Çakına S., Ulu S., Beyazit F., Özen E., Sevinç Postacı E.

REVISTA ROMANA DE MEDICINA DE LABORATOR, vol.2023, no.2, pp.1-6, 2023 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 2023 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.2478/rrlm-2023-0010
  • Journal Name: REVISTA ROMANA DE MEDICINA DE LABORATOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), CAB Abstracts, Directory of Open Access Journals
  • Page Numbers: pp.1-6
  • Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Introduction: In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene

and adiponectin levels in gestational diabetes mellitus (GDM) patients.

Methods: The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM

as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase

chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.

Results: Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype homozygotes

prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).

Conclusion: Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of

the ADIPOQ gene protects against GDM.

Keywords: gestational diabetes mellitus, adiponectin, polymorphism