Association between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients

Creative Commons License

Çakına S., Ulu S., Beyazit F., Özen E., Sevinç Postacı E.

REVISTA ROMANA DE MEDICINA DE LABORATOR, vol.2023, no.2, pp.119-124, 2023 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 2023 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.2478/rrlm-2023-0010
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), CAB Abstracts, Directory of Open Access Journals
  • Page Numbers: pp.119-124
  • Çanakkale Onsekiz Mart University Affiliated: Yes


Introduction: In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene

and adiponectin levels in gestational diabetes mellitus (GDM) patients.

Methods: The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM

as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase

chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.

Results: Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype homozygotes

prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).

Conclusion: Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of

the ADIPOQ gene protects against GDM.

Keywords: gestational diabetes mellitus, adiponectin, polymorphism