Association between adiponectin and <i>ADIPOQ </i>(rs 1501299) gene polymorphism in gestational diabetes mellitus patients

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ÇAKINA S., ULU S., BEYAZIT F., oezen E., Postaci E. S.

REVISTA ROMANA DE MEDICINA DE LABORATOR, sa.2, ss.119-124, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2023
  • Doi Numarası: 10.2478/rrlm-2023-0010
  • Dergi Adı: REVISTA ROMANA DE MEDICINA DE LABORATOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), CAB Abstracts, Directory of Open Access Journals
  • Sayfa Sayıları: ss.119-124
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Introduction In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene and adiponectin levels in gestational diabetes mellitus (GDM) patients.Methods The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.Results Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype ho-mozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).Conclusion Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.