Is hyperbaric oxygen or ozone effective in experimental endocarditis?


Ozkan M. T. A. , Vural A. , Cicek O. F. , Yener A. U. , ÖZCAN S. , Toman H., ...More

JOURNAL OF SURGICAL RESEARCH, vol.202, no.1, pp.66-70, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 202 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jss.2015.12.006
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.66-70

Abstract

Background: Infective endocarditis, a disease with high mortality and morbidity, is most commonly caused by Staphylococcus aureus; mortality and morbidity further increase in the presence of methicillin-resistant strains of S. aureus. Linezolid is the first of the oxazolidinones, a new antibiotic group that has been approved for the treatment of infections caused by gram-positive cocci. Linezolid reduces the quantity of microorganisms in vegetation to some extent; in addition, the use of hyperbaric oxygen (HBO) and ozone (O-3) therapies is likely to improve targeted antibacterial effect.