Cabazitaxel causes a dose-dependent central nervous system toxicity in rats


Karavelioglu E., Gonul Y., Aksit H., Boyaci M. G. , KARADEMIR M., Simsek N., ...Daha Fazla

JOURNAL OF THE NEUROLOGICAL SCIENCES, cilt.360, ss.66-71, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 360
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jns.2015.11.033
  • Dergi Adı: JOURNAL OF THE NEUROLOGICAL SCIENCES
  • Sayfa Sayıları: ss.66-71

Özet

Background: Chemotherapeutic agents may lead to serious neurological side effects, which in turn can deteriorate the quality of life and cause dose limiting. Direct toxic effect or metabolic derangement of chemotherapeutic agents may cause these complications. Cabazitaxel is a next generation semi-synthetic taxane derivative, which is effective in both preclinical models of human tumors sensitive or resistant to chemotherapy and in patients with progressive prostate cancer despite docetaxel treatment.