Cabazitaxel causes a dose-dependent central nervous system toxicity in rats

Karavelioglu, Ergun; Gonul, Yucel; Aksit, Hasan; Boyaci, Mehmet; KARADEMIR, Mustafa; Simsek, Nejdet; Guven, MUSTAFA; Atalay, Tugay; Rakip, Usame

doi:10.1016/j.jns.2015.11.033

Cabazitaxel causes a dose-dependent central nervous system toxicity in rats

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Karavelioglu E., Gonul Y., Aksit H., Boyaci M. G., KARADEMIR M., Simsek N., ...More

JOURNAL OF THE NEUROLOGICAL SCIENCES, vol.360, pp.66-71, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 360
Publication Date: 2016
Doi Number: 10.1016/j.jns.2015.11.033
Journal Name: JOURNAL OF THE NEUROLOGICAL SCIENCES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.66-71
Çanakkale Onsekiz Mart University Affiliated: Yes

Abstract

Background: Chemotherapeutic agents may lead to serious neurological side effects, which in turn can deteriorate the quality of life and cause dose limiting. Direct toxic effect or metabolic derangement of chemotherapeutic agents may cause these complications. Cabazitaxel is a next generation semi-synthetic taxane derivative, which is effective in both preclinical models of human tumors sensitive or resistant to chemotherapy and in patients with progressive prostate cancer despite docetaxel treatment.