Antakya city is at risk because of strong earthquakes occurring in the area, and different soil conditions that can produce variation of the ground motion amplification. Microzonation of cities provides a basis for site-specific hazard analysis in urban settlements. In particular, seismic microzonation can be provided by means of detailed seismic assessment of the area, including earthquake recordings and geological studies. In this paper, we propose a preliminary microzonation map for the city of Antakya, based on the variation of the dominant periods and shear velocities of the sediments covering the area. The periods are retrieved from microtremor measurements conducted at 69 sites, using the horizontal-to-vertical spectral ratio technique. The results of microtremor analysis were compared with data obtained from refraction microtremor (ReMi) measurements at four profiles crossing the studied area. According to the classification of dominant periods, Antakya city can be divided into five zones, probably prone to different levels of seismic hazard. The shorter natural periods are in inner Antakya and both the sides of Asi River (i.e., northern and southern parts). The eastern and western parts of Antakya have maximum dominant periods. The V (s) (30) values were calculated by using the ReMi method along the profiles. Antakya city has V (s) (30) values in the range of category C of the national earthquake hazard reduction programme site classification.