Collagen-based hydrogel films as drug-delivery devices with antimicrobial properties


Sahiner M., Alpaslan D., BİTLİSLİ B. O.

POLYMER BULLETIN, vol.71, no.11, pp.3017-3033, 2014 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.1007/s00289-014-1235-x
  • Journal Name: POLYMER BULLETIN
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.3017-3033
  • Keywords: Hydrogel films, Collagen composites, Drug-delivery devices, Wound dressing materials, Soft polymeric films, GALLIC ACID, MECHANICAL-PROPERTIES, CROSS-LINKING, TANNIC-ACID, SILVER, NANOPARTICLES, PARTICLES, EFFICACY, RELEASE

Abstract

Collagen (coll)-containing hydrogel films were prepared by mixing degraded collagen with monomers such as acrylamide (AAm), and 2-hydroxy ethylmethacrylate (HEMA) before the polymerization/cross-linking of composites as p(coll-co-AAm), and p(coll-co-HEMA), respectively. These materials were used as drug-delivery devices for potential wound dressing materials by loading and releasing of model drugs such as gallic acid (GA) and naproxen (NP). A linear release profile was obtained up to 32-h release from GA-loaded p(coll-co-AAm) interpenetrating polymeric networks films, and 36-h linear release profile of NP for p(coll-co-HEMA). Furthermore, metal nanoparticles such as Ag and Cu prepared within these hydrogel films offered antimicrobial characteristic against known common bacteria such as Escherichia coli, Bacillus subtilis, and Staphylococcus aureus.