Intercellular Adhesion Molecule-1 K469E and Angiotensinogen T207M Polymorphisms in Coronary Slow Flow

GAZİ E., BARUTÇU A., Altun B., Temiz A., Bekler A., Urfali M., ...Daha Fazla

MEDICAL PRINCIPLES AND PRACTICE, cilt.23, sa.4, ss.346-350, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1159/000363451
  • Dergi Adı: MEDICAL PRINCIPLES AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.346-350
  • Anahtar Kelimeler: ICAM1 polymorphism, Angiotensinogen polymorphism, Coronary slow flow, Atherosclerosis, SINGLE-NUCLEOTIDE POLYMORPHISM, MYOCARDIAL-INFARCTION, CONVERTING ENZYME, ARTERY-DISEASE, ENDOTHELIAL FUNCTION, GENE POLYMORPHISMS, HEART-DISEASE, ATHEROSCLEROSIS, RISK, ICAM-1
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Objective: To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). Subjects and Methods: The participants in this study were 48 patients with CSF and 67 patients with normal coronary flow as controls. The K469E polymorphism of ICAM1 (rs5498) and the T207M polymorphism of AGT (rs4762) were determined using the polymerase chain reaction amplification method. Results: Baseline demographic parameters were similar in both groups. The mean thrombolysis in myocardial infarction frame count was significantly higher in patients with CSF (23.8 +/- 5.1) compared to the controls (13.3 +/- 2.6, p < 0.001). A significant association was found between the ICAM1 K allele and CSF (OR: 1.96, 95% CI: 1.15-3.35, p = 0.013). There was no difference in the frequency of AGT T207M genotypes in the patients with CSF and the control subjects. Conclusion: This study showed that K469E polymorphisms of ICAM1 that play a role in atherosclerotic pathogenesis are related to CSF. (C) 2014 S. Karger AG, Basel

Abstract

OBJECTIVE:

To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF).

SUBJECTS AND METHODS:

The participants in this study were 48 patients with CSF and 67 patients with normal coronary flow as controls. The K469E polymorphism of ICAM1 (rs5498) and the T207M polymorphism of AGT (rs4762) were determined using the polymerase chain reaction amplification method.

RESULTS:

Baseline demographic parameters were similar in both groups. The mean thrombolysis in myocardial infarction frame count was significantly higher in patients with CSF (23.8 ± 5.1) compared to the controls (13.3 ± 2.6, p < 0.001). A significant association was found between the ICAM1 K allele and CSF (OR: 1.96, 95% CI: 1.15-3.35, p = 0.013). There was no difference in the frequency of AGT T207M genotypes in the patients with CSF and the control subjects.

CONCLUSION:

This study showed that K469E polymorphisms of ICAM1 that play a role in atherosclerotic pathogenesis are related to CSF.