Single-nucleotide polymorphism in Turkish patients with adolescent idiopathic scoliosis: Curve progression is not related with MATN-1, LCT C/T-13910, and VDR BsmI


Yilmaz H., ZATERİ C. , Uludag A. , Bakar C., Kosar S., Ozdemir O.

JOURNAL OF ORTHOPAEDIC RESEARCH, vol.30, no.9, pp.1459-1463, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1002/jor.22075
  • Title of Journal : JOURNAL OF ORTHOPAEDIC RESEARCH
  • Page Numbers: pp.1459-1463

Abstract

The role of genetics in the etiopathogenesis of adolescent idiopathic scoliosis (AIS) is unclear. In this study, we investigated the relationship between AIS and polymorphisms in MATN-1, LCT C/T-13910, and VDR BsmI genes. 53 Turkish adolescents with diagnosed AIS and 54 healthy adult individuals were included in the study. MATN-1, LCT C/T-13910, and VDR BsmI gene mutations were analyzed with real-time PCR. We did not detect a statistically significant difference between AIS and control groups in respect to those three different gene polymorphisms (p?