Single-nucleotide polymorphism in Turkish patients with adolescent idiopathic scoliosis: Curve progression is not related with MATN-1, LCT C/T-13910, and VDR BsmI


Yilmaz H., ZATERİ C. , Uludag A. , Bakar C., Kosar S., Ozdemir O.

JOURNAL OF ORTHOPAEDIC RESEARCH, cilt.30, ss.1459-1463, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1002/jor.22075
  • Dergi Adı: JOURNAL OF ORTHOPAEDIC RESEARCH
  • Sayfa Sayıları: ss.1459-1463

Özet

The role of genetics in the etiopathogenesis of adolescent idiopathic scoliosis (AIS) is unclear. In this study, we investigated the relationship between AIS and polymorphisms in MATN-1, LCT C/T-13910, and VDR BsmI genes. 53 Turkish adolescents with diagnosed AIS and 54 healthy adult individuals were included in the study. MATN-1, LCT C/T-13910, and VDR BsmI gene mutations were analyzed with real-time PCR. We did not detect a statistically significant difference between AIS and control groups in respect to those three different gene polymorphisms (p?