SOCIAL ISOLATION STRESS REDUCES HIPPOCAMPAL LONG-TERM POTENTIATION: EFFECT OF ANIMAL STRAIN AND INVOLVEMENT OF GLUCOCORTICOID RECEPTORS


Kamal A., Ramakers G. M. J. , Altinbilek B. , Kas M. J. H.

NEUROSCIENCE, vol.256, pp.262-270, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 256
  • Publication Date: 2014
  • Doi Number: 10.1016/j.neuroscience.2013.10.016
  • Title of Journal : NEUROSCIENCE
  • Page Numbers: pp.262-270
  • Keywords: depression, cognitive deficits, activity-dependent synaptic plasticity, SYNAPTIC PLASTICITY, BEHAVIORAL STRESS, PLASMA-CORTICOSTERONE, MEMORY, LTP, CA1, DEPRESSION, INDUCTION, MICE, MODULATION

Abstract

Background: Depressive patients show cognitive impairments that are strongly associated with cortisol levels and hippocampus functioning that interact via unknown mechanisms. In addition, a relation between depression and hippocampal synaptic plasticity was described.