SOCIAL ISOLATION STRESS REDUCES HIPPOCAMPAL LONG-TERM POTENTIATION: EFFECT OF ANIMAL STRAIN AND INVOLVEMENT OF GLUCOCORTICOID RECEPTORS


Kamal A., Ramakers G. M. J., Altinbilek B., Kas M. J. H.

NEUROSCIENCE, vol.256, pp.262-270, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 256
  • Publication Date: 2014
  • Doi Number: 10.1016/j.neuroscience.2013.10.016
  • Journal Name: NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.262-270
  • Keywords: depression, cognitive deficits, activity-dependent synaptic plasticity, SYNAPTIC PLASTICITY, BEHAVIORAL STRESS, PLASMA-CORTICOSTERONE, MEMORY, LTP, CA1, DEPRESSION, INDUCTION, MICE, MODULATION
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Background: Depressive patients show cognitive impairments that are strongly associated with cortisol levels and hippocampus functioning that interact via unknown mechanisms. In addition, a relation between depression and hippocampal synaptic plasticity was described.