A bio-imprinted urease biosensor: Improved thermal and operational stabilities


Teke M., Sezginturk M. K. , Dinçkaya E., Telefoncu A.

TALANTA, cilt.74, ss.661-665, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier identifier

Özet

Despite the increasing number of applications of biosensors in many fields, the construction of a steady biosensor remains still challenging. The high stability of molecularly bio-imprinted enzymes for its substrate can make them ideal alternatives as recognition elements for sensors. Urease (urea aminohydrolase, EC 3.5.1.5), which catalysis the hydrolysis of urea to ammonia and carbon dioxide, has been used in immobilized form in artificial kidney for blood detoxification. According to one report approximately half a million patients worldwide are being supported by haemodialysis.