Akademik Veri Yönetim Sistemi
MICROCHEMICAL JOURNAL, cilt.224, 2026 (SCI-Expanded, Scopus)
Ornidazole (ORDZ) overuse can lead to disequilibrium in the microbiome system of humans and bring bacterial antibiotic resistance. Therefore, the development of more sensitive and practical methods for ORDZ monitoring has become an important concern. In the proposed work, a novel hybrid system including electropolymerized 2,2 '-((1E,1 ' E)-(((9H-fluorene-9,9-diyl)bis(4,1-phenylene))bis (azanylylidene))bis(methanylylidene))bis(4-bromo phenol) (AF-SA) and functionalized multi-walled carbon nanotubes (f-MWCNTs) modified glassy carbon electrode (poly(AF-SA)@f-MWCNTs/GCE) was prepared for sensitive voltammetric determination of ORDZ. Compared with bare GCE, f-MWCNTs/GCE, and poly(AF-SA)@GCE, the combination of poly(AF-SA) and fMWCNTs exhibits a remarkable electrocatalytic efficiency based on the reduction of ORDZ according to the cyclic voltammetry and differential pulse voltammetry measurements. The composite electrode exhibits two linear detection ranges (3.0-300 and 300-1500 & micro;M) with a high sensitivity of 730 & micro;A mM- 1 cm-2 and a lower detection limit of 0.90 & micro;M. The ORDZ sensing system displayed an outstanding feasibility performance towards determining ORDZ in pharmaceutical tablets, artificial blood serum, and natural spring water samples with acceptable recovery rates, high accuracy, and precision. Moreover, the poly(AF-SA)@f-MWCNTs/GCE showed fulfilling repeatability, reproducibility, long-term stability, and remarkable selectivity for determination of ORDZ. Overall, the poly(AF-SA)@f-MWCNTs/GCE sensor offers a sensitive and reliable platform for ORDZ detection in real samples.