308G/A and 238G/A polymorphisms in the TNF-alpha gene may not contribute to the risk of arthritis among Turkish psoriatic patients

IŞIK S., SILAN F., KILIÇ S., Hiz M. M., Ogretmen Z., ÖZDEMİR Ö.

EGYPTIAN RHEUMATOLOGIST, cilt.38, sa.4, ss.313-317, 2016 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.ejr.2016.02.005
  • Dergi Adı: EGYPTIAN RHEUMATOLOGIST
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.313-317
  • Anahtar Kelimeler: Psoriasis, Psoriatic arthritis, TNF-alpha-308G/A promoter polymorphism, TNF-alpha-238G/A promoter polymorphism, Tumor necrosis factor (TNF alpha), PASI, SUSCEPTIBILITY, ASSOCIATION, THERAPY, REGION
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Introduction: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine playing a key role in the pathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). TNF alpha gene promoter region single nucleotide polymorphisms (SNPs) affect the clinical course, severity and the response to the treatment.