308G/A and 238G/A polymorphisms in the TNF-alpha gene may not contribute to the risk of arthritis among Turkish psoriatic patients


IŞIK S., SILAN F., KILIÇ S., Hiz M. M. , Ogretmen Z., ÖZDEMİR Ö.

EGYPTIAN RHEUMATOLOGIST, vol.38, no.4, pp.313-317, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ejr.2016.02.005
  • Journal Name: EGYPTIAN RHEUMATOLOGIST
  • Journal Indexes: Emerging Sources Citation Index, Scopus
  • Page Numbers: pp.313-317
  • Keywords: Psoriasis, Psoriatic arthritis, TNF-alpha-308G/A promoter polymorphism, TNF-alpha-238G/A promoter polymorphism, Tumor necrosis factor (TNF alpha), PASI, SUSCEPTIBILITY, ASSOCIATION, THERAPY, REGION

Abstract

Introduction: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine playing a key role in the pathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). TNF alpha gene promoter region single nucleotide polymorphisms (SNPs) affect the clinical course, severity and the response to the treatment.