308G/A and 238G/A polymorphisms in the TNF-alpha gene may not contribute to the risk of arthritis among Turkish psoriatic patients


IŞIK S. , SILAN F. , KILIÇ S. , Hiz M. M. , Ogretmen Z. , ÖZDEMİR Ö.

EGYPTIAN RHEUMATOLOGIST, cilt.38, ss.313-317, 2016 (ESCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 38 Konu: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.ejr.2016.02.005
  • Dergi Adı: EGYPTIAN RHEUMATOLOGIST
  • Sayfa Sayıları: ss.313-317

Özet

Introduction: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine playing a key role in the pathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). TNF alpha gene promoter region single nucleotide polymorphisms (SNPs) affect the clinical course, severity and the response to the treatment.