308G/A and 238G/A polymorphisms in the TNF-alpha gene may not contribute to the risk of arthritis among Turkish psoriatic patients


IŞIK S. , SILAN F. , KILIÇ S. , Hiz M. M. , Ogretmen Z. , ÖZDEMİR Ö.

EGYPTIAN RHEUMATOLOGIST, vol.38, no.4, pp.313-317, 2016 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ejr.2016.02.005
  • Title of Journal : EGYPTIAN RHEUMATOLOGIST
  • Page Numbers: pp.313-317

Abstract

Introduction: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine playing a key role in the pathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). TNF alpha gene promoter region single nucleotide polymorphisms (SNPs) affect the clinical course, severity and the response to the treatment.