Effect of allulose administration on glucose metabolism: a systematic review and meta-analysis of randomized controlled trials Efecto de la administración de alulosa sobre el metabolismo de la glucosa: una revisión sistemática y metaanálisis de ensayos controlados aleatorios
Gaceta Medica de Mexico, cilt.162, sa.3, ss.256-268, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 162 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.24875/gmm.m26001086
- Dergi Adı: Gaceta Medica de Mexico
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Fuente Academica Plus, EMBASE, MEDLINE, Directory of Open Access Journals, DIALNET
- Sayfa Sayıları: ss.256-268
- Anahtar Kelimeler: Allulose, Glucose, Insulin, Meta-analysis, Randomized controlled trial
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet
Özet
Background: Some studies have reported that allulose consumption improves postprandial glucose and insulin levels, while others indicate minimal or no effects. Therefore, we assessed the impact of allulose administration on glycemic parameters through a meta-analysis of randomized controlled trials (RCTs). Material and methods: The search was made in PubMed, Web of Science, Scopus, ClinicalTrials.gov, Cochrane Library, and Google Scholar databases. RCTs with either parallel or cross-over design, investigating the effects of allulose on glycemic parameters, and exhibiting complete outcomes at baseline and the end of follow-up in both intervention and control groups were eligible for meta-analysis. Nevertheless, uncontrolled trials, non-randomized trials, trials without a control group, observational studies, and incomplete outcomes at baseline or the end of the follow-up were exclusion criteria. Meta-analysis was performed using comprehensive meta-analysis V2 software. Results: The meta-analysis of 12 clinical trials showed that allulose significantly decreased plasma glucose in the subgroup with high glycemic index control groups (mean difference [MD] = −4.23 mg/dL (95% confidence interval [CI]: −7.11, −1.35), p = 0.004), but no significant effect in the low glycemic index control groups (MD = 0.68 mg/dL (95% CI: −1.84, 3.21), p = 0.59). Allulose did not affect insulin levels in studies with either a high (MD = −1.52 mU/mL (95% CI: −4.18, 1.13), p = 0.26) and low (MD = −0.19 mU/mL (95% CI: −1.33, 0.95), p = 0.74) glycemic index control group. Finally, allulose significantly reduced the area under the curve of plasma glucose in both subgroups with high (MD = −2.34 (95% CI: −2.94, −1.74), p < 0.001) and low (MD = −0.56 (95% CI: −0.99, −0.14), p = 0.009) glycemic index control intervention, but this variable was not changed for insulin in studies with high (MD = −0.37 (95% CI: −1.01, 0.26), p = 0.25) and low (MD = −0.21 (95% CI: −0.45, 0.03), p = 0.08) glycemic index control group. Conclusion: We suggest that the administration of allulose reduces plasma glucose but does not affect insulin levels.