Applications of electrochemical immunosensors for early clinical diagnostics


Bahadir E. B. , Sezginturk M. K.

TALANTA, vol.132, pp.162-174, 2015 (Peer-Reviewed Journal) identifier identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 132
  • Publication Date: 2015
  • Doi Number: 10.1016/j.talanta.2014.08.063
  • Journal Name: TALANTA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.162-174
  • Keywords: Biosensor, Cancer biomarkers, Immunosensor, Electrochemical biosensors, Early diagnosis, PROSTATE-SPECIFIC ANTIGEN, LABEL-FREE IMMUNOSENSOR, SELF-ASSEMBLED MONOLAYERS, SCREEN-PRINTED ELECTRODE, CARDIAC TROPONIN-T, SENSITIVE AMPEROMETRIC IMMUNOSENSOR, SIGNAL AMPLIFICATION STRATEGY, GLASSY-CARBON ELECTRODE, MODIFIED GOLD ELECTRODE, MESOPOROUS SILICA NANOPARTICLES

Abstract

Cancer and cardiovascular diseases are the major threats to global health. Hence, there is a growing demand for a range of portable, rapid and low cost biosensing devices for the detection of these diseases. Electrochemical immunosensors are simple, rapid, reliable and inexpensive devices and they have sensitive detection limits to monitor both levels of the biomarkers in normal and patient serum. Due to the specific binding of antibody to its corresponding antigen, immunosensors based on antibody antigen interaction are one of the most widely used analytical techniques in the quantitative detection of these diseases. The changed levels of markers in patients are associated with diseases. In this article the biosensors and biomarkers, which were commonly used in terms of monitoring the diagnosis and treatment of cancer and cardiac diseases, are reviewed. In addition, the developed biosensors are compared in terms of precision, reproducibility, regeneration, stability and specificity. (C) 2014 Elsevier B.V. All rights reserved.