Applications of electrochemical immunosensors for early clinical diagnostics

Bahadir E. B., Sezginturk M. K.

TALANTA, cilt.132, ss.162-174, 2015 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 132
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.talanta.2014.08.063
  • Dergi Adı: TALANTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.162-174
  • Anahtar Kelimeler: Biosensor, Cancer biomarkers, Immunosensor, Electrochemical biosensors, Early diagnosis, PROSTATE-SPECIFIC ANTIGEN, LABEL-FREE IMMUNOSENSOR, SELF-ASSEMBLED MONOLAYERS, SCREEN-PRINTED ELECTRODE, CARDIAC TROPONIN-T, SENSITIVE AMPEROMETRIC IMMUNOSENSOR, SIGNAL AMPLIFICATION STRATEGY, GLASSY-CARBON ELECTRODE, MODIFIED GOLD ELECTRODE, MESOPOROUS SILICA NANOPARTICLES
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Hayır

Özet

Cancer and cardiovascular diseases are the major threats to global health. Hence, there is a growing demand for a range of portable, rapid and low cost biosensing devices for the detection of these diseases. Electrochemical immunosensors are simple, rapid, reliable and inexpensive devices and they have sensitive detection limits to monitor both levels of the biomarkers in normal and patient serum. Due to the specific binding of antibody to its corresponding antigen, immunosensors based on antibody antigen interaction are one of the most widely used analytical techniques in the quantitative detection of these diseases. The changed levels of markers in patients are associated with diseases. In this article the biosensors and biomarkers, which were commonly used in terms of monitoring the diagnosis and treatment of cancer and cardiac diseases, are reviewed. In addition, the developed biosensors are compared in terms of precision, reproducibility, regeneration, stability and specificity. (C) 2014 Elsevier B.V. All rights reserved.