NS5A resistance - associated substitutions in chronic hepatitis C patients with direct acting antiviral treatment failure in Turkey


SAYAN M., Yildirim F. S. , AKHAN S., YILDIRIM A. A. , ŞİRİN G., Cabalak M., ...Daha Fazla

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.95, ss.84-89, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 95
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ijid.2020.03.061
  • Dergi Adı: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Sayfa Sayıları: ss.84-89

Özet

Objectives: Chronic hepatitis C (CHC) is now a more curable disease with new direct acting antivirals (DAA). Although high sustained virologic response rates, failures still occur in DAA regimens. Our objective in this study was to characterize the real-life presence of clinically relevant resistance - associated substitutions (RASs) in the HCV NS5A gene in CHC patients whose DAA regimen has failed.