Research Information System
Demiroğlu Bilim Üniversitesi Florence Nightingale Tıp Dergisi, vol.8, no.1, pp.11-18, 2022 (Peer-Reviewed Journal)
Objectives: In this study we aimed to describe the clinical features, treatment, and outcomes of patients with COVID-19 admitted to the
intensive care unit.
Patients and methods: In this retrospective, observational study, we enrolled 116 patients (69 males, 47 females; mean age: 66.9±13.6 years;
range, 23 to 93 years) with COVID-19 confirmed by PCR tests who were admitted to Manavgat State Hospital. Demographic data, symptoms, laboratory
findings, comorbidities, treatment, and outcomes were collected between August 1, 2020, and January 1, 2021. Data were compared between patients
who died and those who survived.
Results: A total of 62 patients died, with a 53.4% mortality rate, while 54 recovered. The demographic analysis indicated that mortality for
patients in the older age group (i.e., ≥60 years) was higher than those in the younger age group (84%, 68.5%). In addition, seven laboratory
parameters were statistically associated with mortality: neutrophil (p<0.001), C-reactive protein (p<0.001), urea (p<0.001), lactate dehydrogenase
(p<0.001), ferritin (p<0.001), D-dimer (p<0.001), and Troponin-I (p<0.001). Sixty-three patients (55%) required mechanical ventilation, and only
one patient (2%) survived after mechanical ventilation. The median time from intensive care unit admission to death was 11.5 days (interquartile
range 7.0-17). At 28 days and 60 days, 57 (49%) and four (3.5%) patients died, respectively. On the 72nd day, one (0.9%) patient died.
Conclusion: Neutrophil, C-reactive protein, urea, lactate dehydrogenase, ferritin, D-dimer, and Troponin-I counts were found to be predictive of death
in these patients. Further studies are needed to aid efficient recognition and management of severe COVID-19 patients in our population.
Keywords: COVID-19, CRP, intensive care units, Manavgat, non-survivors, survivors.