Histological and Macroscopic Evaluation of Plant Secretion-Derived Bioscaffolds on Critical Size Defects of Rabbit Mandibles: A Preliminary Report


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ÇETİN GENÇ Ç., DEĞİRMENCİ A., YILMAZ DAĞDEVİREN H. D., DENİZ Y., ARSLAN Y. E., DERKUŞ B.

TURKISH ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGERY (TAOMS 30th International Scientific Congress), Antalya, Türkiye, 17 - 21 Kasım 2023, ss.121-124

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.121-124
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

Objective: The study aimed to explore the impact of bioengineered scaffolds derived from plant secretions on critical size

defects in the rabbit mandible.

Materials and Methods: 36 male rabbits were included in the study. Bilateral mandibular defects of 10 mm in diameter and

4 mm in depth were surgically prepared in experiments. The QSM/nHAp-based scaffolds were implanted on one side, and

the other side was left empty. The subjects were sacrificed on the 10th, 21st, 45th, and 90th days. Hemotoxylin-eosin staining

was used as a general tissue stain, and Masson's trichrome staining technique revealed calcium deposits and deposits

histologically.

Results: In the control group, the surface of the defect showed signs of smooth healing. However, there were significant gaps

in the healing process on the 45th and 90th days, and the cylindrical defect showed signs of fibrotic healing. In the

experimental group, graft material was observed on day 10. On the 21st day, the graft underwent resorption at the cavity's

base, forming new bone tissue in its place. Histological evaluation showed that new bone formation in the defect was better

in the experimental group than in the control group. Histologic evaluation showed that new bone formation in the defect

was better in the experimental group than in the control group.

Conclusion: The hydrophilic, flexible, porous structure and durable characteristics of QSM-nHAp bioscaffolds make QSM-

nHAp composites a promising option for non-load-bearing applications, particularly in research related to craniomaxillofacial

re-modeling.

Key Words: Quince seed mucilage, Bone tissue engineering, Rabbit mandible