Akademik Veri Yönetim Sistemi
TURKISH ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGERY (TAOMS 30th International Scientific Congress), Antalya, Türkiye, 17 - 21 Kasım 2023, ss.121-124
Objective: The study aimed to explore the impact of bioengineered scaffolds derived from plant secretions on critical size
defects in the rabbit mandible.
Materials and Methods: 36 male rabbits were included in the study. Bilateral mandibular defects of 10 mm in diameter and
4 mm in depth were surgically prepared in experiments. The QSM/nHAp-based scaffolds were implanted on one side, and
the other side was left empty. The subjects were sacrificed on the 10th, 21st, 45th, and 90th days. Hemotoxylin-eosin staining
was used as a general tissue stain, and Masson's trichrome staining technique revealed calcium deposits and deposits
histologically.
Results: In the control group, the surface of the defect showed signs of smooth healing. However, there were significant gaps
in the healing process on the 45th and 90th days, and the cylindrical defect showed signs of fibrotic healing. In the
experimental group, graft material was observed on day 10. On the 21st day, the graft underwent resorption at the cavity's
base, forming new bone tissue in its place. Histological evaluation showed that new bone formation in the defect was better
in the experimental group than in the control group. Histologic evaluation showed that new bone formation in the defect
was better in the experimental group than in the control group.
Conclusion: The hydrophilic, flexible, porous structure and durable characteristics of QSM-nHAp bioscaffolds make QSM-
nHAp composites a promising option for non-load-bearing applications, particularly in research related to craniomaxillofacial
re-modeling.
Key Words: Quince seed mucilage, Bone tissue engineering, Rabbit mandible