The influence of alpha-adducin gene polymorpism on response of blood pressure to exercise in patients with hypertension

Alioglu E., Ercan E., Tengiz I., Turk U. O., ERGÜN M., Akgoz S., ...More

ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, vol.10, no.5, pp.400-404, 2010 (SCI-Expanded) identifier identifier identifier


Objective: Clinical studies have indicated that an excessive response of blood pressure (BP) to exercise predicts risk of cardiovascular mortality. Although the mechanism responsible for the excessive BP response to exercise has not been revealed, there are some plausible mechanisms linking with underlying structural abnormalities in the cardiovascular system. Carriers of the Trp460 allele of the alpha-adducin Gly460Trp polymorphism have an increased risk of hypertension. The aim of the present study was to examine the influence of alpha-adducin gene polymorphism on response of BP to exercise in patients with hypertension.