The effect of aspirin on electrically-stimulated penile erection in rats

Kapicioglu S., Mollamehmetoglu M., Kutlu N., ÇAN G., Ozgur K.

Annals of Medical Sciences, vol.8, no.1, pp.7-10, 1999 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 1999
  • Journal Name: Annals of Medical Sciences
  • Journal Indexes: Scopus, Academic Search Premier
  • Page Numbers: pp.7-10
  • Keywords: Aspirin, Electrically stimulation, Penile erection, Rat
  • Çanakkale Onsekiz Mart University Affiliated: No


Purpose: The effect of aspirin on erectile function was assessed in rats. Methods: Animals were fasted and intraperitoneally anesthetized with pentobarbital. A cannula was placed in the trachea and the femoral vein was cannulated for IV infusion. All animals received IV infusion of 0.9 saline 1 ml/h during the study. The hypogastric and pelvic nerve, major pelvic ganglion, and the nerve fibers to the lower genitourinary tract were identified. In 20 animals, these nerves were stimulated unilaterally by bipolar silver wire electrodes. Stimulation was repeated every 15 min. for one hour. After measurement of penile erection with video camera for basal value, twenty animals were divided into two groups (n:10). Group I received 1 ml/h saline IV for 60 min. Group II received an IV bolus injection of aspirin (ASA) (60 mg/kg), followed by IV infusion of ASA (40 mg/kg/h). Results: After administration of aspirin or saline, penile erection levels reduced linearly with time in both groups, but the levels in the aspirin group were lower than the levels in the control group. This reduction was significantly different from the control group only at 30 min (P < 0.05), and from baseline (P < 0.01) at all times. Conclusion: Our findings show that aspirin has an inhibiting effect on penile erection.