Vitamin D Deficiency Related to Polycystic Ovary Syndrome and DHEAS

TJOD ARALIK 2020, İstanbul, Turkey, 4 - 06 December 2020, pp.0-1

Süreyya Demir1, İbrahim Uğraş Toktaş2, Bülent Demir2, Mehmet Nuri Duran2

1 Dokuz Eylül University Faculty of Medicine, Department of Gynecology and Obstetrics, İzmir, Turkey

2 Çanakkale Onsekiz Mart University Faculty of Medicine, Department of Gynecology and Obstetrics,

Çanakkale, Turkey

PURPOSE: There were studies indicating a correlation between vitamin D levels and polycystic ovary

syndrome (PCOS), as well as studies suggesting no significant relationship between PCOS patients

and controls. Furthermore, the relationship of vitamin D deficiency with clinical findings and

dehidroepiandrosteron sülfat (DHEAS) has not been adequately investigated. Therefore, the aim of this

study is to reveal the relationship of vitamin D deficiency with PCOS, clinical findings of PCOS and

DHEAS.

METHODS: Two hundred and thirty patients diagnosed with polycystic ovary syndrome according to

2003 Rotterdam criteria were included to the study. Age and BMI of patients, application complaints,

duration of menstruation, blood hormone profiles and biochemical parameters were recorded from the

electronic data of the hospital information and management system. Kruskal Wallis, Mann Whitney U,

Chi-square and Oneway Anova tests were used.

RESULTS: Among 230 PCOS women 46.6% of women had severe deficiency of vitamin D, %43.4 had

deficiency, 5.9% had insufficiency and 4.1% had sufficiency. There was no correlation between the

levels of vitamin D and DHEAS. It was found no significant relationship of vitamin D and DHEAS levels

with clinical findings including hirsutism, infertility and duration of menstruation. BMI was also correlated

positively to vitamin D levels.

CONCLUSION: Although lower vitamin D levels were detected in patients with PCOS, this decrease

was not confirmed by clinical symptoms. This may be due to the high incidence of vitamin D deficiency

in the general population. No significant relationship between DHEAS and vitamin D levels indicate that

high levels of DHEAS in PCOS patients may be due to pathways other than vitamin D deficiency.

Anahtar Kelimeler: polycystic ovary syndrome, vitamin D, DHEAS, dehidroepiandrosteron sülfat