The effect of extremely high glucose concentrations on 21 routine chemistry and thyroid Abbott assays: interference study

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Cuhadar S., Koseoglu M., Cinpolat Y., Bugdayci G., Usta M., Semerci T.

BIOCHEMIA MEDICA, vol.26, no.1, pp.53-60, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.11613/bm.2016.004
  • Journal Name: BIOCHEMIA MEDICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.53-60
  • Keywords: assay interference, glucose interference, preanalytical phase, creatinine, Jaffe kinetic assay, thyroid function tests, PERITONEAL-DIALYSIS, CREATININE DETERMINATION, CALCIUM
  • Çanakkale Onsekiz Mart University Affiliated: No

Abstract

Introduction: Extremely high glucose concentrations have been shown to interfere with creatinine assays especially with Jaffe method in peritoneal dialysate. Because diabetes is the fastest growing chronic disease in the world, laboratories study with varying glucose concentrations. We investigated whether different levels of glucose spiked in serum interfere with 21 routine chemistry and thyroid assays at glucose concentrations between 17-51 mmol/L.