Main purpose of this study was to investigate genetic polymorphisms of Saanen (S), Maltese (M) and Turkish Hair (TH) goats based on erythrocyte potassium and glutathione types. It was also designed to detect the association between these components and some blood parameters depending on the breed comparisons. The phenotypic and alleles frequencies were calculated for potassium and glutathione types of all three breeds. The difference between low and high potassium (LK and HK, respectively) types for the means of erythrocyte potassium concentration (K-e) were statistically important for all breeds (p<0.01). The significant relationships between erythrocyte potassium types and blood parameters of erythrocyte sodium (Na-e), whole blood potassium (K-wb), plasma potassium (K-p), erythrocyte potassium (K-e) were observed for S and TH goats. On the other hand, the important relationships were detected between erythrocyte potassium types and blood parameters of whole blood sodium (Na-wb), Na-e K-wb, K-p, K-e, total monovalent cation concentration in erythrocyte (Na-e+K-e) for M goat breed (p<0.05). The correlation coefficient between Na-e and K-e blood parameters was important and it was ranged from -0.26 to -0.34. In addition, Maltese goat breeds had a higher K-e than the others but Na-e was higher in TH goats. Even if parity and birth type differences were not statistically important for all blood parameters, there was indication of significant differences for these values except hematocrit value (PCV), Na-p and GSH concentrations depending on the potassium types within breed (p<0.05) and also among all breed analyses (p<0.001).